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Grantee in the News: Dena Dubal on klotho and cognitive function in Cell Reports and Popular Science

Aug 10
2017

Grantee in the News: Dena Dubal on klotho and cognitive function in Cell Reports and Popular Science View MoreBACK


On August 8, 2017, Cell Reports published research from 2015 AFAR Research Grant for Junior Faculty recipient, 2009 Paul B. Beeson Emerging Leaders Career Development Award in Aging scholar, and 1998 Glenn/AFAR Scholarships for Research in the Biology of Aging recipient Dena Dubal, MD, PhD.

The study, Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice, tested young mice, aged mice, and mice genetically altered to have brains similar to people with Alzheimer’s or Parkinson’s disease. These mice were injected with a portion of the hormone klotho.

The researchers found that the mice that had daily klotho injections were better able to navigate a complex maze than their control group peers.

In a related feature story, Dr. Dubal told Popular Science: “We tested them two weeks later in a different cognitive test and they were still smarter, which suggested that getting the klotho protein into their bodies combined with brain training and stimulation had a long-lasting effect in their brain.”

Read the full study in Cell Reports here.

Read the Popular Science feature article here.

Dena Dubal, MD, PhD is an Assistant Professor at the UCSF Memory and Aging Center.


Learn more about Dena Dubal, MD, PhD and what inspired her to enter the field of aging research and what impact she hopes her research will make thanks to AFAR’s support in our Grantee Spotlight interview here.





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