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Board Member in the News: David Sinclair, PhD Uncovers Pivotal Finding in Repairing DNA Damage

Mar 24
2017

Board Member in the News: David Sinclair, PhD Uncovers Pivotal Finding in Repairing DNA Damage View MoreBACK

On March 24, 2017, Science Journal published significant researched partially funded by AFAR and lead by AFAR Board Member and 2000 Research Grant Recipient David Sinclair, PhD, on preventing age-related and radiation-induced DNA damage using the nucleotide, NMN.

Dr. Sinclair and his research team found that mice pre-treated with NMN showed lower levels of DNA damage after undergoing harmful radiation. Additionally, they also determined older mice given NMN had a decline in molecular markers that signal DNA damage, and an equal ability to repair damaged DNA as young mice.

The study reveals remarkable insights in mice that are anticipated to carry over in the upcoming human trials. Sinclair agrees: “Our results unveil a key mechanism in cellular degeneration and aging but beyond that they point to a therapeutic avenue to halt and reverse age-related and radiation-induced DNA damage”.   

Dr. Sinclair explains the impact of this research in a short video here.

The Science article is available by subscription only, but an abstract can be read here.

David A. Sinclair, PhD, is as a Professor of Genetics and co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School.


For more information on DNA and its relation to aging, explore AFAR’s expert-edited Infoaging Guide to DNA.





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