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AFAR Grantee, Awardee, and Board member in the News: Bonkowski, Guarente, Mitchell, and Sinclair research on sirutins and longevity published in Cell

Mar 30
2018

AFAR Grantee, Awardee, and Board member in the News: Bonkowski, Guarente, Mitchell, and Sinclair research on sirutins and longevity published in Cell View MoreBACK

On March 22, 2018, Cell published research on sirutins and longevity co-authored by several AFAR experts:

• 2011 Ellison Medical Foundation/ AFAR Postdoctoral Fellows and 2007 Eweson Series Lecturer Michael Bonkowski, Ph.D.
• 2015 Irving S. Wright Award of Distinction winner Leonard Guarente, Ph.D.
• 2009 Glenn Foundation for Medical Research and AFAR Grant for Junior Faculty recipient James Mitchell, Ph.D.; and
  2000 Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty recipient and Board member David Sinclair, Ph.D.

In “Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging,” the researchers present findings on vascular aging and NAD+ booster nicotinamide mononucleotide (NMN) that “have implications for improving blood flow to organs and tissues, increasing human performance and reestablishing a virtuous cycle of mobility in the elderly.”

The research was also picked up by Health News Digest, which explains that the research team “have shown for the first time how a well-studied enzyme called SIRT1 declines in the blood vessels with age and that restoring it reverses the effects of vascular aging. After receiving a supplement called NAD+ precursor nicotinamide mononucleotide (NMN), older mice had the number of capillaries and capillary density found in much younger mice, and improved endurance by up to 80 percent.”

In a related article published in Science Daily, Guarente states: “we’ll have to see if this plays out in people, but you may actually be able to rescue muscle mass in an aging population by this kind of intervention.”

The published research is available by purchase or subscription only here, but the related articles can be viewed in Health News Digest and Science Daily here and here.


Michael Bonkowski, Ph.D. is a Post-doctoral Research Fellow at Harvard Medical School in the Sinclair Lab.

Leonard Guarente, Ph.D. is a Novartis Professor of Biology at the Massachusetts Institute of Technology and the Director of The Paul F. Glenn Center for Biology of Aging Research at MIT.

James R. Mitchell, Ph.D. is an Associate Professor of Genetics and Complex Diseases at Harvard T. H. Chan School of Public Health

David Sinclair, Ph.D. is a Professor in the Department of Genetics at Harvard Medical School and Co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging.





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