News
News

The latest updates from AFAR.

AFAR Experts in the News: Nir Barzilai, Matt Kaeberlein, James Kirkland, and David Sinclair on interventions to target aging in Popular Science

Jun 29
2018

AFAR Experts in the News: Nir Barzilai, Matt Kaeberlein, James Kirkland, and David Sinclair on interventions to target aging in Popular Science

On June 12, 2018, Popular Science spotlighted innovative interventions to extend healthspan including the Targeting Aging with Metformin (TAME) Trial, rapamycin, senolytic agents, and NAD + molecules. These research strategies are driven by a range of AFAR experts, as featured in the article: • AFAR Deputy Scientific Director, 1997 Beeson Scholar and 1994 AFAR Research Grant recipient, Nir Barzilai, M.D. • 2007 Glenn/AFAR Breaktroughs in Gerontology (BIG) Award recipient Matt Kaeberlein, Ph.D. • 2012 Glenn/AFAR Breakthroughs in Gerontology (BIG) Award recipient and President-elect James L. Kirkland, M.D., Ph.D. • 2000 AFAR Research Grant recipient and Board member David Sinclair, Ph.D. The…


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AFAR in the News: Next Avenue Column by Steven N. Austad on the Dog Aging Project

Jun 27
2018

AFAR in the News: Next Avenue Column by Steven N. Austad on the Dog Aging Project

On June 26, 2018, Next Avenue published the latest column by AFAR Scientific Director Steven N. Austad, Ph.D. “What Can Dogs Teach Us About Aging Well?” explores research to understand what canine longevity reveals about human healthspan. The column focuses on The Dog Aging Project, which is led 2007 Glenn Foundation for Medical Research Breakthroughs in Gerontology (BIG) Award recipient Matt Kaeberlein, Ph.D. and 1996 AFAR Research Grant for Junior Faculty and 2010 Glenn/AFAR Breakthroughs in Gerontology Award recipient Daniel Promislow, Ph.D. Doctors Kaeberlein and Promislow lead research at the University of Washington Nathan Shock Center of Excellence in…


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Incredible: 2017 Annual Report

Jun 25
2018

Incredible: 2017 Annual Report

The American Federation for Aging Research is pleased to release our 2017 annual report, themed “Incredible.” The report’s theme is inspired by the new PBS documentary, Incredible Aging: Adding Life to Our Years, featuring over one dozen AFAR experts. This year’s report highlights three extraordinary scientists who are driving innovative age-related research that received early support through an AFAR grant. First, Comparing Animal Models Bolsters Research On Aging and Cancer highlights the research of 2005 AFAR Research Grantee Vera Gorbunova, Ph.D. Dr. Gobunova believes that understanding the mechanisms that have naturally evolved in long-lived animals…


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AFAR experts in the News: Randall Bateman, Carlos Cruchaga, and Celeste Karch on genes and Alzheimer’s disease

Jun 25
2018

AFAR experts in the News: Randall Bateman, Carlos Cruchaga, and Celeste Karch on genes and Alzheimer’s disease

On June 8, 2018, Genome Medicine published research co-authored by: • 1997 Glenn/AFAR Scholarship for Research in the Biology of Aging, 2007 Beeson Scholar, and 2015 recipient of the AFAR-administered MetLife Foundation Award for Medical Research in Alzheimer’s Disease, Randall Bateman, M.D. • AFAR 2013 New Investigator in Alzheimer's Disease recipient Carlos Cruchaga, Ph.D. • 2017 New Investigator Awards in Alzheimer’s Disease recipient Celeste Karch, Ph.D. In “Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure,” the researchers conclude “that genetic risk factors associated with AD etiology have a…


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2018 Scientific Meetings

Jun 25
2018

2018 Scientific Meetings

From June 3–6, 2018, AFAR hosted its annual scientific meetings in Santa Barbara, California. Over 100 attendees--including AFAR grantees, senior leaders the field, and representatives from foundations--convened to hear about the most recent research from AFAR-supported investigators, and to share insights on emerging directions in the field. The meeting provided valuable opportunities for the attendees to learn from each other’s work and to engage in discussions and potential collaborations. First, AFAR and The Rosalinde and Arthur Gilbert Foundation co-hosted the New Investigators in Alzheimer’s Disease Grantee Meeting, which featured Data Blitz sessions from current and former grantees, networking…


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Grantee in the News: Reisa Sperling in the Washington Post on early biomarkers of Alzheimer’s disease

Jun 22
2018

Grantee in the News: Reisa Sperling in the Washington Post on early biomarkers of Alzheimer’s disease

On June 15, 2018, The Washington Post highlighted 2003 Beeson Scholar Reisa Sperling, M.D. M.M.Sc. “Five myths about Alzheimer’s disease” highlights Dr. Sperling’s research  with the Harvard Aging Brain Study on “the slow transition from a healthy brain to Alzheimer’s by studying the same normal middle-aged and older adults for years.” The overall goal of the Harvard Aging Brain Study is to elucidate the earliest changes in molecular, functional and structural imaging markers that signal the transition from normal cognition to progressive cognitive decline along the trajectory of preclinical…


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Grantee in the News: Leora Horwitz in JAMA Internal Medicine on the importance of personal protective equipment and patient safety

Jun 21
2018

Grantee in the News: Leora Horwitz in JAMA Internal Medicine on the importance of personal protective equipment and patient safety

On June 11, 2018, JAMA Internal Medicine published an editorial by 2010 Beeson Scholar Leora Horwitz, M.D. In “The Importance of User-Centered Design and Evaluation,” Dr. Horwitz looks at a qualitative study recently published in JAMA Internal Medicine that found “that errors and lapses in safety while donning, wearing, or doffing PPE (personal protective equipment) were frequent, although not quantified.” Dr. Horwitz comments on the reasons for these violations: “Given the complexity, time intensity, and material waste involved in using PPE, clinicians appeared to be making a deliberate cost-benefit assessment in avoiding PPE use in perceived low-risk…


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Grantee in the News: Domenico Praticò in Molecular Neurobiology on reversing brain damage from dementia in mice

Jun 20
2018

Grantee in the News: Domenico Praticò in Molecular Neurobiology on reversing brain damage from dementia in mice

On June 7, 2018, Molecular Neurobiology published research co-authored by 1997 AFAR Research Grant and 1999 AFAR/Pfizer Innovations in Aging Research Award recipient Domenico Praticò, M.D. In “Learning Impairments, Memory Deficits, and Neuropathology in Aged Tau Transgenic Mice Are Dependent on Leukotrienes Biosynthesis: Role of the cdk5 Kinase Pathway,” Dr. Pratico and his team found that “the first demonstration that the leukotriene biosynthesis is functionally involved at the later stages of the tau pathological phenotype and represents an ideal target with viable therapeutic potential for treating human tauopathies.” In a related article in ScienceAlert, Dr. Praticò…


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Grantee in the News: Reisa Sperling in The Boston Globe on intervening during preclinical stages of Alzheimer’s disease

Jun 18
2018

Grantee in the News: Reisa Sperling in The Boston Globe on intervening during preclinical stages of Alzheimer’s disease

On June 11, 2018, The Boston Globe spotlighted 2003 Beeson Scholar Reisa Sperling, M.D. M.M.Sc. ”Can this doctor figure out how to stop Alzheimer’s before it starts?” spotlights Dr. Sperling’s research on the preclinical phase of Alzheimer’s disease through the buildup of amyloid plaques and tau tangles. The article states: “Sperling thinks early intervention may soon emerge as the treatment of choice for a huge swath of patients. Her work on the preclinical phase over the last decade has led to a new biological definition of Alzheimer’s: one based…


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AFAR Experts in the News: Nathaniel David and Judith Campisi in Forbes on UNITY Biotechnology’s research to target senescent cells

Jun 14
2018

AFAR Experts in the News: Nathaniel David and Judith Campisi in Forbes on UNITY Biotechnology’s research to target senescent cells

On June 5, 2018, Forbes spotlighted AFAR board member Nathaniel David, Ph.D. and 1990 Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty recipient Judith Campisi, Ph.D. “A Biotech Entrepreneur Aims To Help Us Stay Young While Growing Old” focuses on UNITY Biotechnology, a startup co-founded by Nathaniel David and Judith Campisi. The mission of UNITY Biotechnology is to extend human healthspan by using biotechnology and medicine to target age-related diseases. UNITY hopes to develop medicines that remove senescent cells, called senolytics. However, removing senescent cells has not been tested on humans yet. “The problem is…


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Grantee in the News: Kristine Yaffe in WebMD on dementia risk factors

Jun 05
2018

Grantee in the News: Kristine Yaffe in WebMD on dementia risk factors

On May 30, 2018, WebMD highlighted the research and insights of 2001 Paul B. Beeson Emerging Leaders Career Development Award in Aging Scholar recipient Kristine Yaffe, M.D. In “Risk Factors That Put You on The Road to Dementia,” Dr. Yaffe lends her insights on multiple dementia risk factors. “It’s not yet definitive, but in the past 5 years, we’ve made progress on identifying modifiable risk factors for which the evidence is pretty strong,” Dr. Yaffe states. The article spotlights Dr. Yaffe’s co-authored research in JAMA Neurology on mild head injuries and the increased…


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Grantee in the News: Reisa Sperling in Reader’s Digest on early signs of Alzheimer’s disease and the A4 study

Jun 04
2018

Grantee in the News: Reisa Sperling in Reader’s Digest on early signs of Alzheimer’s disease and the A4 study

On May 29, 2018, Reader’s Digest spotlighted the insights and research of 2003 Paul B. Beeson Emerging Leader Career Development Award in Aging recipient Reisa Sperling M.D., M.M.Sc. “10 Early Signs of Alzheimer’s Every Adult Should Know” highlights a new clinical trial on Alzheimer’s disease led by Dr. Sperling. The A4 study "will evaluate patients with evidence of Alzheimer’s damage in the brain but who still have normal thinking and memory function. The trial will randomly assign groups to receive medication, and researchers will determine over three years whether the drugs…


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Grantee in the News: Jerome Mertens’ research in Cell Reports and PsychCentral on mitochondrial dysfunction and age-related diseases

Jun 01
2018

Grantee in the News: Jerome Mertens’ research in Cell Reports and PsychCentral on mitochondrial dysfunction and age-related diseases

On May, 29, 2018, Cell Reports published research co-authored by 2015 Irene Diamond Fund/AFAR Postdoctoral Transition Award in Aging recipient Jerome Mertens, Ph.D. “Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile” concludes “that iNs are a valuable tool for studying mitochondrial aging and support a bioenergetic explanation for the high susceptibility of the brain to aging.” The research was also picked up by PsychCentral, where Dr. Mertens notes the difference in the mitochondria of older donors: “Pretty much every area we looked at — functional, genetic, and morphological — had…


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Board member in the news: Rudolph E. Tanzi in The New York Times on the link between viruses and Alzheimer’s disease

Jun 29
2018

Board member in the news: Rudolph E. Tanzi in The New York Times on the link between viruses and Alzheimer’s disease

On June 21, 2018, The New York Times highlighted the research of AFAR board member Rudolph E. Tanzi, Ph.D. “A Common Virus May Play A Role in Alzheimer’s Disease, Study Finds” focuses on research that shows a link between viruses and Alzheimer’s disease--“particularly two types of herpes that infect most people as infants and then lie dormant for years.” The link between herpes and Alzheimer’s is further becoming more credible through findings by Dr. Tanzi and Dr. Robert Moir, to be published in Neuron. The article states: “Their new…


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