On November 3rd, 2025, Nature Medicine published new research by Beeson Scholar Reisa Sperling, MD, on the potential connection between moderate exercise and delaying the onset of Alzheimer’s disease.
In a related Mass General Brigham press release, Dr. Sperling shares, “These findings show us that it’s possible to build cognitive resilience and resistance to tau pathology in the setting of preclinical Alzheimer’s disease. This is particularly encouraging for our quest to ultimately prevent Alzheimer’s disease dementia, as well as to decrease dementia due to multiple contributing factors.”
Since being published, this research has received coverage in a range of notable outlets worldwide, including:
Dr. Sperling is a 2003 Paul B. Beeson Emerging Leaders Career Development Award in Aging recipient.
Read the research, “Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease”, in Nature Medicine here.
Read more in a related Mass General Brigham Press Release here.
