John Collins
John Collins - PhD
The Irene Diamond Fund/AFAR Postdoctoral Transition Awards in Aging - 2018
John Collins

John Collins - PhD

Postdoctoral Fellow - University of North Carolina at Chapel Hill
North Carolina, USA


The Irene Diamond Fund/AFAR Postdoctoral Transition Awards in Aging - 2018

SIRT6 as a novel therapeutic target in aging and osteoarthritis

Osteoarthritis (OA) is a leading cause of disability that affects over 30 million adults in the United States.  The major risk factor is aging. There are currently no disease-modifying treatments for OA and the exact mechanisms how aging contributes to the development of OA remains unknown. Dr. John Collins aims to identify the specific age-related pathways responsible for cartilage degradation and cell death. This research will specifically seek to determine the effect of reactive oxygen species (ROS) to reduce activity of a gene related to aging (SIRT6) in vitro in normal, young, old, and OA human cells. Dr. Collins will also study the effects of cartilage-specific deletion of SIRT6 on the development and progression of OA in vivo in mouse models. The finding of this study could lead to new therapies with a more targeted approach aimed at specific pathways affected by aging and oxidative stress to be developed to slow or stop OA progression.

View all grantees for The Irene Diamond Fund/AFAR Postdoctoral Transition Awards in Aging in 2018

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