Jenna Bartley
Jenna Bartley - PhD
The Irene Diamond Fund/AFAR Postdoctoral Transition Awards in Aging - 2018
Jenna Bartley

Jenna Bartley - PhD

Postdoctoral Fellow - University of Connecticut School of Medicine
Connecticut, USA


The Irene Diamond Fund/AFAR Postdoctoral Transition Awards in Aging - 2018

The effect of metformin on influenza vaccine responses and T cell function in the elderly

With age, cell-mediated immune responses are diminished, which leads to an increased susceptibility to infection and poor vaccination responses. Dr. Bartley’s current research investigates how changes in the cellular metabolism of T cells influence these alterations, particularly in regard to the response to flu vaccination. Flu is among the leading killers of older adults; however reduced vaccine responses render them unprotected.

In the proposed research, Dr. Jenna Bartley will investigate the effects of targeting cellular metabolism with metformin, a widely used FDA-approved diabetes drug, to improve the T cell metabolic profile and overall immune responses to flu vaccination in older adults. The effects of metformin on T cells phenotype and function will be examined both in vitro and in vivo in older adults. The goal of the study is to gather information about if metformin can rejuvenate the aging immune system’s T cells both in vitro and in vivo and potentially improve vaccine efficacy in this vulnerable population. These findings could lead to improved strategies for preventing infections disease mortality and developing more effective vaccine responses in older adults.

View all grantees for The Irene Diamond Fund/AFAR Postdoctoral Transition Awards in Aging in 2018

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