Isha Jain
Isha Jain - PhD
AFAR Research Grants for Junior Faculty - 2018
Isha Jain

Isha Jain - PhD

Faculty Fellow - University of California, San Francisco
California, USA


AFAR Research Grants for Junior Faculty - 2018

Hypoxia as a therapy for age-associated proteotoxic stress and neurodegeneration

Epidemiological studies show a relationship between low oxygen levels (hypoxia) and longevity, with 7 of the 10 longest-lived US counties located at high altitudes in Colorado. Hypoxia-tolerant species, such as the naked mole rat, tend to be the longest-lived. Studies in worms have shown the activation of hypoxia transcriptional program increases longevity and protects against proteotoxicity. These previous studies, among others, indicate that oxygen levels have an impact on aging and longevity. In the proposed research, Dr. Isha Jain will investigate the role of oxygen in disease and metabolism, and explore the possibility of varying oxygen levels as therapy for age-associated neurodegeneration.

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