Monoclonal Antibodies
Breast Cancer

Breast Cancer Latest Research


Monoclonal Antibodies Help Stop the Spread of Breast Cancer

One of the greatest dangers to breast cancer patients is the potential for the cancer to spread to other parts of the body, most commonly the bones and lungs.

Recently, Dr. Richard Kremer and a team of researchers at the McGill University Health Centre identified a specific protein, parathyroid hormone-related protein, that is implicated in the spread of breast cancer and pioneered a strategy for decreasing the body's production of it.  By developing a monoclonal antibody-a molecule that mimics the immune system's natural response to invaders-against this protein, the team was able to halt the growth of human breast tumors implanted in animal models, as well as their metastatic spread, opening the door to clinical trials in the near future.

For cancer patients with more aggressive forms of breast cancer that do not respond to existing treatment, Dr. Kremer sees "...a potential for better treatment of the disease and improvement in the quality of life for a very significant number of patients."

Next to lymphoma, breast cancer is the malignancy most responsive to monoclonal antibody treatment. Researchers are constantly discovering new ways to use these antibodies, several of which may actually be bringing a cure for breast cancer within sight. 

Journal Reference:
Jiarong Li, Andrew C. Karaplis, Dao C. Huang, Peter M. Siegel, Anne Camirand, Xian Fang Yang, William J. Muller, Richard Kremer. PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI46134