Glenn/AFAR Breakthroughs in Gerontology Award for 2015

David Marcinek

David Marcinek

Associate Professor, University of Washington


Mitochondrial oxidative stress alters aged muscle function through oxidation of the thiol proteome Loss of muscle function with age is an important public health concern due to its role in increased morbidity, loss of independence, and nursing home placement. Despite this, there are few treatment options available to improve muscle performance in the elderly. That...

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David Sabatini

David Sabatini

Member/Principal Investigator, Whitehead Institute for Biomedical Research


Reversing age-associated deterioration in intestinal stem and niche cells by targeting the mTORC1 and PPARδ signaling pathways Higher organisms have evolved specialized organs that can absorb, metabolize and distribute key nutrients necessary for survival. The mammalian intestine is one of the first sites of nutrient sensing and is maintained by long-lived intestinal stem cells. In...

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