2017

Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty


Vittorio Sebastiano, PhD

Assistant Professor, Stanford University

Transient reprogramming for efficient cell-autonomous reversal of age-associated phenotypes

Dr. Sebastiano is working to develop a system that can lead to the partial or total reversal of aging effects at the cell, tissue, and organ system level. This is known as rejuvenation.

Dr. Sebastiano’s approach is based on the technology of induced pluripotent stem cell (iPSC) reprogramming. iPSC’s are stem cells derived from skin or blood cells that have been reprogrammed back into an embryonic-like, pluripotent state. That means they can give rise to many different cell types, enabling the development of various types of human cells needed for therapeutic purposes.

Remarkably, iPSC’s and cells derived from them display a more youthful nature than the original somatic cells. However, these derivation procedures are still being developed for lab use and cannot be applied in a live organism, in which iPSC’s spontaneously form tumors. Dr. Sebastiano’s preliminary work shows that inducing just the early reprogramming events can erase many of the aspects of cellular age in multiple human cell types without losing their identity.

Building on this work, Dr. Sebastiano’s team will investigate the underlying molecular mechanisms that drive age reversal and establish a restoration of functionality for tissues. They hope to transition the technology for direct application in the body. Their work could help to restore youthful capabilities and functionality to aged organisms, including humans.

More 2017 Recipients of this Grant

Luis Batista, PhD

The impact of progressive telomere shortening on mitochondria function and energy metabolism of human stem cells

Peter Douglas, PhD

Stress-mediated actin phosphorylation in endocytosis and age regulation

Sergei Doulatov, PhD

The role of autophagy in human hematopoietic stem cell aging

Michael Garratt, PhD

Sensory perception of the social environment: regulation of mouse development, metabolism and aging

Vyacheslav Labunskyy, PhD

Endoplasmic Reticulum (ER) stress resistance and longevity

Darcie Moore, PhD

The molecular mechanisms underlying asymmetric segregation of aging factors in mammalian neural stem cells

Archana Unnikrishnan, PhD

Role of DNA methylation in Dietary Restriction mediated insulin sensitivity

Rui Xiao, PhD

Cold-Shock Proteins (CSPs) in stress response and lifespan modulation

Amir Zarrinpar, MD, PhD

The relationship of gut luminal dynamics and aging-related circadian dysfunction and dysmetabolism