2019

Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research


Higuchi Sanabria headshot

Ryo Higuchi-Sanabria, PhD

Postdoctoral Fellow, University of California, Berkeley

More than just a load control: cytoskeletal form and function during aging

Many cellular functions decline in efficacy during the aging process. The actin cytoskeleton is no exception, and exhibits marked decline in structural integrity and function as we age. The integrity of the cytoskeleton is essential to diverse cellular processes and disruption of the organization and dynamics of the actin cytoskeleton leads to age-associated symptoms and diseases, ranging from cancer to neurodegeneration. Dr. Higuchi-Sanabria proposes a multipronged approach to understand how the regulatory network involved in cytoskeletal maintenance deteriorates during aging, and how this contributes to the physiological consequences of aging.

More 2019 Recipients of this Grant

Laura Bott, PhD

Elucidating intra- and inter-individual variability in proteostasis network capacity during aging

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Nirmalya Dasgupta, PhD

A role for histone chaperone HIRA in cytoplasmic DNA sensing and senescence-associated inflammatory signaling

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Yoko Henderson, PhD

Determining the effects of late-life initiated caloric restriction on aging-related cognitive decline, frailty, and H2S production

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Li Li, MD, PhD

A mitochondrial membrane-spanning ternary complex is a drug target for aging and Parkinson's disease

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Elise Marsan, PhD

Glial dysfunctions in brain aging and neurodegenerative diseases

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Mikolaj Ogrodnik, PhD

Targeting lipid metabolism to reduce pro-inflammatory phenotype and viability of senescent cells

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Seungjin Ryu, PhD

The role of a matricellular adipokine in aging by integration of immune-metabolic response

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Kevin Stein, PhD

Defining the role of co-transitional proteostasis in aging and age-related pathologies

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Matthew Ulgherait, PhD

Engineering the microbiome to ameliorate age-related intestinal diseases and extend lifespan in Drosophila

Matthew Ulgherait