Regulation of the aging process by molecules and pathways involved in organ communication
Dr. Perrimon’s laboratory is interested in dissecting the “Inter-organ Communication Network”, identifying new hormonal systems and determining their physiological roles and regulation. For his BIG-supported research, Dr. Perrimon will use a simple model, the fly, to take a systematic approach to identifying molecules involved in organ communication that influence aging. His hypothesis is that aging is a systems problem and that it is important to understand how the aging of one organ affects the aging of others. If we can characterize key molecules involved in organismal aging this can lead to the search for drugs that can delay the effects of aging.