A role for histone chaperone HIRA in cytoplasmic DNA sensing and senescence-associated inflammatory signaling
Significant advances have been made in therapies that slow age-related aging processes. One strategy selectively targets senescent cells, abnormal cells that accumulate with age. Dr. Dasgupta's research uses another aspect of senescent cell biology to provide an alternative way to reduce the inflammatory properties of Senescence Associated Inflammatory Phenotype (SASP.) The main goals of this research are to better understand the inflammatory properties of senescent cells and to use this knowledge to perform proof-of-concept validation of a novel target for inhibition of senescence-associated inflammation.
