Targeting lipid metabolism to reduce pro-inflammatory phenotype and viability of senescent cells
Cells, when damaged, often do not die, but become senescent (“zombie”) and start producing nefarious substances. This way, senescent cells damage surrounding healthy cells, cause tissue inflammation and contribute to age-related diseases. Recent evidence has shown that the elimination of these senescent cells can slow down the onset of a range of age-related diseases such as Alzheimer’s disease, atherosclerosis and diabetes. Dr. Ogrodnik’s research is aimed at understanding senescent cells and finding out how to disable their aggressive behavior towards healthy cells.
