Jason Butler
Jason Butler - PhD
AFAR Research Grants for Junior Faculty - 2014
Jason Butler

Jason Butler - PhD

Assistant Professor - Weill Cornell Medical College
New York, United States


AFAR Research Grants for Junior Faculty - 2014

Rejuvenation of aged vascular niches to enhance hematopoietic function

Aging in the blood system is associated with dramatic changes in stem cell function.  In addition to increasing in number and losing self-renewal potential, old blood stem cells exhibit a myeloid bias and increased propensity to develop hematologic malignancies.  While some of these changes are thought to partially rely on cell-intrinsic changes, emerging data suggests that some of these may also be regulated by the bone marrow microenvironment. Dr. Butler’s group has demonstrated that blood vessels from the bone marrow are indispensable in supporting blood stem cell function at steady state and following myeloablative insult.  The finding that blood vessels from the bone marrow release growth factors that maintain blood stem cells has opened up new avenues for the discovery of novel therapeutics to protect the blood system against a wide range of disorders. Given that the aging process leads to a multitude of diseases that affect nearly all systems of the body, including cardiovascular and hematological disorders, Dr. Butler is focusing his research efforts on identifying alterations in bone marrow blood vessels that lead to a decrease in blood stem cell function during the aging process and to develop therapeutic strategies to rejuvenate the blood system.  The success of these studies may lead to the development of therapeutic strategies for the rejuvenation of the blood stem cell niche and help increase our body's ability to cure age-related diseases.

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