Congcong He
Congcong He - PhD
The New Investigator Awards in Alzheimer's Disease - 2017
Congcong He

Congcong He - PhD

Assistant Professor - Northwestern University
Illinois, USA


The New Investigator Awards in Alzheimer's Disease - 2017

Role of Becn2 in modulation of cannabinoid signaling and Alzheimer’s disease

How autophagy proteins and inducers regulate AD progression is poorly understood. Regulating Aβ processing and secretion has thought to be the main function of autophagy in AD. Dr. He’s proposed studies will change this paradigm from a cell biology perspective, by establishing a new model in which activation of autophagy prevents amyloid toxicity by enhancing cannabinoid signaling in AD, in addition to the commonly believed role in Aβ processing. To test the hypothesis, Dr. He designed a pilot drug screen and identified novel lead autophagy-inducing compounds that can restore memory in an AD mouse model. She aims to study their functions and mechanisms in the regulation of Becn2-mediated cannabinoid signaling and AD pathogenesis. Results from the project will demonstrate the function of the autophagy-related gene Becn2 in AD for the first time, and will help understand whether Becn2 is a novel therapeutic target in AD and how autophagy inducers work to prevent the pathogenesis of AD.

View all grantees for The New Investigator Awards in Alzheimer's Disease in 2017

STAY CONNECTED