Carlos Aguilar
Carlos Aguilar - PhD
Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty - 2019
Carlos Aguilar

Carlos Aguilar - PhD

Assistant Professor - University of Michigan
Michigan, USA


Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty - 2019

Deconstructing stem cell aging through interact-omics

Dr. Aguilar’s lab has potential to advance knowledge about an “old” question, which is “why do we age?” Specifically, his lab is trying to figure out why stem cells that reside in skeletal muscle become dysfunctional through aging. His lab’s studies aim to provide a framework for how stem cells communicate with other cell types and how tissues make collective decisions.

The overarching objective of the AFAR project is to describe the interrelationship of muscle stem cells (MuSCs) with the neuromuscular synapse during aging. The specific goals of this proposal are to demonstrate how critical synergy between muscle stem cells and motor neuron (MN)-proximal myonuclei is broken during aging and to expose how age-associated alterations in MNs influences MuSC functions and rescue of MNs in turn restores MuSC functions.

View all grantees for Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty in 2019

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