What inspired you to pursue aging research?
The aging society has emerged as a global challenge. It is evident that the number of elderly individuals, including members of my own family, is increasing. Recognizing the influence of age on the development and progression of various diseases, I firmly believe that aging is a fundamental aspect of overall human health. I have observed that the rate of aging differs among individuals, even among those with similar genetic backgrounds, depending on their lifestyle choices. This observation suggests that the aging process can be influenced and possibly manipulated. Considering these factors, I am compelled to study aging as a focal point of my research.
In your view, what does AFAR mean to the field, and what does it mean, for you, to receive an AFAR grant now?
AFAR plays a vital role in advancing the aging research field by supporting scientists, promoting collaboration, and advocating for increased investment in aging-related studies. Its efforts contribute to our understanding of aging and age-related diseases, with the ultimate goal of improving the health and quality of life of older adults.
Having a fellowship from AFAR holds significant meaning for my development as an independent researcher. Firstly, receiving this grant serves as a substantial confirmation of the validity and merit of my research plan. The recognition from peer review instills a newfound confidence in the research direction I am pursuing. Secondly, the research funding provided by this fellowship will enable me to conduct several crucial experiments, which will play a pivotal role in bolstering the foundation of my future research proposal. Lastly, the fellowship's mentorship support will prove invaluable in guiding my independent research journey and establishing vital connections for potential future research collaborations.
What is exciting about your research’s potential impact?
Metabolism has emerged as a fundamental factor influencing aging and the development of aging-related diseases. Gaining insights into the functionality of metabolism pathways can offer novel targets for interventions to counteract aging. Interestingly, the propionyl-CoA metabolism pathway is conserved across various organisms, yet its function remains inadequately explored.
Based on my preliminary data, it appears that this metabolic pathway plays a role during cell senescence, and its significance might have been overlooked. With my research proposal, I aim to be the first to investigate its function in aging and aging-related diseases, contributing valuable knowledge to this field. These findings have the potential to lead to the identification of effective interventions that can target propionate metabolism for the prevention and treatment of aging-related diseases.
How would you describe your research to a non-scientist?
As we get older, our bodies can have trouble processing and distributing nutrients, leading to a build-up of certain metabolites. This can contribute to health problems that come with aging. In this project, I propose to study a specific process called propionate metabolism and its novel connection to aging. I will focus on a metabolite called methylmalonic acid and how it affects aging in mice. I will also determine how a process called protein propionylation is involved in cell senescence. By understanding these processes, I will reveal new ways to prevent and treat age-related diseases.
