What inspired you to pursue aging research?
Our interest in aging research stems from our research into the causes of metabolic diseases and their impact on health. The incidence of obesity and diabetes rises with age and shortens lifespan. In addition, numerous reports have suggested that calorie restriction and possibly rapamycin can extend life . Pertinent to this, we have recently found that rapamycin mitigates obesity by restoring leptin effects on POMC neurons in the hypothalamus, see here. This raised the possibility that the hypothalamus, which controls a multitude of homeostatic systems, might play a role in the aging process and associated morbidities and we thus proposed a series of experiments to evaluate this possibility. The mystery surrounding the aging process is a compelling and potentially tractable problem and we are excited to have an opportunity to contribute to our understanding of it.
In your view, what does AFAR mean to the field, and what does it mean, for you, to receive an AFAR grant now?
AFAR has been advancing aging research by promoting innovation and supporting exploratory research that is often unfunded by other agencies. It thus fills a vital niche in this field. We are thrilled to be the recipients of a Glenn Foundation Discovery Award and relish the opportunity to contribute to this field which we would not be in a position to enter without this support. The resources that are provided will enable us to explore several innovative ideas that will hopefully make an important impact.
What is exciting about your research’s potential impact?
The exciting potential impact of my research lies in uncovering how aging affects the hypothalamus. This could lead to new insights and treatments for age-related conditions, improve understanding of aging mechanisms, and offer innovative strategies to enhance healthspan.
How would you describe your research to a non-scientist?
My research explores how aging impacts the brain, specifically the hypothalamus. By studying individual brain cells, we aim to understand the changes that occur as we age. This knowledge could help develop new treatments for age-related diseases and improve overall health as we get older.
