Uncovering sex-specific epigenetic ageing molecules in response to exercise
In this large-scale project, Dr. Eynon aims to uncover sex-specific biomarkers that slow the aging process. Using advanced bioinformatics and statistical methods, his lab will integrate more than 4000 human muscle samples, and analyze more than half a million molecular profiles in males and females across the human lifespan. He will describe the molecules that change as we age in human muscle at multiple layers of cell regulation. It will provide novel insights into different ways people can preserve their muscle strength and endurance as they age, and how they can optimize their lifestyle to live healthier for longer, depending on their biological sex. With this information, evidence-based, personalized and targeted health interventions that support health aging can be developed, bringing significant economic and social benefits to the world’s population.
