Measurement of the conservation in mammalian cells of the effects of lifespan-extending tRNA synthetase inhibitors
Dr. McCormick has been fascinated by aging as a scientific puzzle for as long as he can remember, in part because it is puzzling that related types of animals can have such different natural lifespans. Dr. McCormick’s lab wants to understand how and why humans age, and to understand how we might affect this process in order to postpone the onset of diseases of aging like cancer, Alzheimer's disease, and others. In his lab’s latest projects, they have found drugs that can increase the lifespan of yeast and worms. He will now test whether these drugs work the same way in mammalian cells and could extend healthspan in mice, and potentially in humans as well.
