Role of bone marrow macrophage iron accumulation in inflammaging
Iron is crucial for vital body functions like oxygen transport and energy production. However, as we age, too much iron can accumulate and cause harm. Excessive iron has been linked to age-related diseases, cognitive decline, and shorter lifespans, as it can trigger cell death/damage or "senescence" (cell aging). Dr. Batoon’s research found that iron builds up in bone marrow macrophages - cells vital for immune function and removing damaged cells - as they age. This iron buildup may cause macrophage dysfunction, contributing to aging. Dr. Batoon’s project aims to understand how iron affects these cells and explore therapies that combine iron removal (chelation) with drugs that eliminate aged cells (senolytics). This dual approach could reduce iron overload and improve immune health, offering promising new treatments for aging and related conditions.
