Molecular mechanisms of Annexin-mediated membrane repair in preventing premature senescence
As we age, our cells face a slow-down, entering a state called senescence where they stop dividing but refuse to die. These so-called "zombie cells" aren’t harmless—they release signals that can trigger inflammation and speed up aging. Recent research has uncovered a surprising culprit: damage to cell membranes, the protective barriers that maintain balance and allow communication. Over time, viral and bacterial infections can weaken these membranes, nudging cells into senescence. Dr. Bao seeks to unravel the underlying molecular mechanism, aiming to prevent and repair membrane damage involved in premature senescence. Therefore, the proposed study could facilitate therapeutic developments that keep our cells younger for longer, transforming the twilight years from a period of decline into a vibrant extension of life.
