Targeting Thymic Involution: Novel Solutions for Age-Related Immune Decline
As people age, their immune systems gradually weaken, increasing vulnerability to infections, cancer, and contributing to the development or progression of chronic diseases such as cardiovascular disease, type 2 diabetes, and Alzheimer’s. Dr. Martens’ lab investigates how aging reshapes the environments and cellular programs that support immune function. Their research aims to understand the molecular and structural changes that occur within the immune system over time. Using advanced genetic models and tissue engineering techniques, the lab will identify key pathways that drive immune aging and test strategies to slow or reverse these changes. The ultimate goal of the work in the Martens lab is to discover new therapeutic targets that can help maintain a stronger, more resilient immune system in older adults. By uncovering the root causes of age-related immune decline, this work aims to support healthier aging and improve disease resistance across the lifespan.
