Aged Adipose B cells, inflammation and impaired metabolism
Dr. Camell’s research focuses on immunometabolic changes that occur during aging. Older adults are at the highest risk for metabolic disease, chronic inflammation and morbidity during infection. Obesity increases with age and has a major detrimental effect on whole body metabolic disease, aging and responses to infection. Her AFAR-supported research will investigate the expansion of B cells, cells traditionally known to be required for antibody production, during aging. Her research has found that these cells expand in metabolic tissues and are known to inhibit tissue function and promote inflammation. Her lab will investigate inflammatory mechanisms that drive their expansion, their contribution to cellular senescence and how they respond during infections. Overall, this project is focused on understanding the role tissue resident B cells play in regulating inflammation, tissue function and immunity during aging.
