Advancing Research
by funding Grant Programs and Fellowships
Driving Innovation
by guiding studies such as the FAST Initiative, the SuperAgers Initiative, and the TAME Trial
Furthering the Field
by supporting the infrastructure of three NIA Initiatives and leading the Amplifying Geroscience Initiative.
Top Breakthroughs driven by AFAR Experts
Delaying Disease by Targeting Aging
Saving Costs by Extending Healthspan
What are the Hallmarks of Aging?
What is Geroscience?
What is the Longevity Dividend?
Dr. Frost is dedicated to studying fundamental processes in cell biology that drive cell death in aging-related neurodegenerative disorders, including Alzheimer’s disease. In the proposed work, early discovery will take place in Drosophila, a model organism that is amenable to genetic manipulation, and is well suited for investigating issues of causality in disease processes. Drosophila work will be complemented with comparative analyses in postmortem human brain tissue to ensure that any findings are relevant to human disease. Dr. Frost has previously shown that that the nuclear envelope, the spherical membrane that contains a cell’s DNA, undergoes significant three-dimensional architectural changes in Alzheimer’s disease. The overall goal of the proposed project is to determine if neurodegeneration in Alzheimer’s disease is caused by changes in nuclear architecture that cause basic nuclear processes to go awry.
