Macrophage niches in aging
As we age, our bodies begin to lose physiological resilience – the ability to bounce back after an injury or illness. An important factor underlying physiological resilience is the capacity of individual tissues to heal and stay healthy or maintain “tissue integrity.” Understanding the biology of how tissues maintain integrity would also help understand what mechanisms slow or break down with age. Dr. Subramanian will study the role of immune cells in maintaining such tissue integrity, and how aging impacts their function. Her lab will apply multimodal technologies to generate molecular data from tissues, and computational methods to infer immune signaling pathways that rewire with aging.
