Inside AFAR
Inside AFAR

Insights, Views, and Interviews

Dec 5
12:39 pm

Grantee Spotlight Interview: Subhash Katewa View MoreBACK

AFAR’s grant programs in the biology of aging are central to our mission to support and advance healthy aging through biomedical research. At leading institutions nationwide, our grantees hard work, ingenuity, and leadership are advancing cutting-edge research that will help us all live healthier, longer.


AFAR is proud to introduce our newest grantees. In this Grantee Spotlight interview,  Subhash Katewa, PhD, shares what inspired him to enter the field of aging research and how AFAR’s support's has impacted his research.


Subhash Katewa, PhD

Assistant Professor, Buck Institute for Research on Aging

2014, AFAR Research Grant for Junior Faculty





What inspired you to get into aging research?

In humans, aging is not simply about getting old, its the plethora of diseases that comes with old age. What inspires me is that if we can understand the molecular basis behind the process of aging, we can actually slow down aging,  reduce the incidence of age-related diseases significantly and enhance the quality of life.


How will AFAR’s support further your research at this point in your career?

When you apply for an AFAR grant, you know that your work will be evaluated and critiqued by the best in the Aging field, so the satisfaction that your scientific views are appreciated by the aging community is the biggest encouragement a young scientist can get. Also, as I am starting my own lab, the support from AFAR will go a long way in order to understand and elucidate novel molecular pathways that can modulate aging and extend healthspan.


What’s exciting about your research’s potential impact?

My research suggests a potential role for circadian clocks in mediating the lifespan extension by dietary restriction. The impact is that it provides a novel and crucial target for longevity that is amenable to both pharmacological and environmental manipulations. Also, as it’s downstream of dietary restriction pathway, is it possible that by simply modulating the clocks, can we get full benefit of dietary restriction without any restriction.


In three sentences, how would you describe your research?

I am trying to understand why and how an organism ages and is there ways by which we can increase the healthy lifespan beyond what they normally live. The questions we are asking are, for example, why a fruit fly that normally lives for only two months, lives more than three months when kept on restricted diet. What cellular and molecular pathways are altered when an organism is on dietary restriction and can we pharmacologically modulate these pathways to extend healthy lifespan. This could help us design new drugs that can slowdown the aging process and increase your playtime with your great-grandson.