Andreas Pfenning
Andreas Pfenning - PhD
AFAR Research Grants for Junior Faculty - 2018
Andreas Pfenning

Andreas Pfenning - PhD

Assistant Professor - Carnegie Mellon University
Pennsylania, USA


AFAR Research Grants for Junior Faculty - 2018

Cell type-specific epigenetic decay underlying brain aging

The epigenome of a cell is the group of proteins that sits on the genome and ensures a cell is performing its role in the system.  In the proposed research, Dr. Andreas Pfenning will test the idea that disrupting these epigenome proteins leads to overall brain aging. Dr. Pfenning’s laboratory will isolate a subtype of neuron particularly vulnerable to the aging process in older and younger mice. Within that population of cells, they will look for signature of age-dependent epigenetic decay by measuring the epigenetic and gene expression state. They will also look for signs that transcriptional differences can be driven by DNA damage using a mouse model of aging. The goal of this study it to provide insight into the basis mechanisms of aging in the brain and to lay the foundation for future experiments that link molecular mechanisms to neural circuits and cognition.

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