Amy Gleichman
Amy Gleichman - PhD
The Irene Diamond Fund/AFAR Postdoctoral Transition Awards in Aging - 2018
Amy Gleichman

Amy Gleichman - PhD

Postdoctoral Fellow - University of California, Los Angeles
California, USA


The Irene Diamond Fund/AFAR Postdoctoral Transition Awards in Aging - 2018

Astrocytic regulation of synapse formation and elimination in aged mice after stroke

Stroke is a leading cause of death and disability. However, few treatment options exist to enhance stroke recovery. While significant progress is being made to understand molecular changes from stroke, most of the studies use young adult animals. This removes age-related variables, and possibly limits how the interventions that could develop from these studies would translate to patients.

In the proposed research, Dr. Amy Gleichman will investigate the manipulation of astrocytes for stroke recovery. Astrocytes are the most prevalent cells in the brain. They play many roles in the brain, including driving neural plasticity through synapse formation and elimination. Dr. Gleichman will focus on how astrocyte cells can influence neuronal connectivity after stroke and how those functions could be altered to promote repair. Dr. Gleichman will also investigate the ways astrocyte responses change with age, especially as neuronal connectivity can be influenced by age. This study could lead to clear targets for repairing neuronal connectivity after stroke and lead to stroke recovery for both young and older patients.

View all grantees for The Irene Diamond Fund/AFAR Postdoctoral Transition Awards in Aging in 2018

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