2004 Beeson Scholars
Sandy Chang, M.D., Ph.D., MD Anderson Cancer Center: "Telomere Induced Genomic Instability in Premature Aging"
Cathleen Colon-Emeric, M.D., Duke University Medical Center: "Evidence-Based Medicine in the Skilled Nursing Facility"
William Dale, M.D., Ph.D., University of Chicago: "Emotions in Medical Decision Making in Older Adults"
Lee Goldstein, M.D., Ph.D., Harvard Medical School/Brigham and Women's Hospital: "Alzheiimer's Disease Beta-Amyloid in the Lens"
Cary Gross, M.D., Yale University: "The Impact of Comorbidity on Older Cancer Patients"
John Lehman, M.D., Washington University: "Mitochondria Control by PCG-1a in Young and Aging Heart"
Andrew Lieberman, M.D., Ph.D., University of Michigan: "Modifiers of Polyglutamine Toxicity"
Atul Malhotra, M.D., Ph.D., Harvard Medical School/Brigham and Women's Hospital: "Aging Influence on the Development of Sleep Apnea"
Marcin Sadowski, M.D., New York University School of Medicine: "Blocking ApoE/ABeta Binding as a novel AD therapy"
Catherine Sarkisian, M.D., University of California, Los Angeles School of Medicine: "Intervention to Raise Octogenarians' Walking Levels"
Clemens Scherzer, M.D., Harvard Medical School/Brigham and Women's Hospital: "Genomic and Genetic Analysis of Parkinson's Disease"
Lisa Silbert, M.D., Oregon Health Sciences University: "White Matter Change and CNS Process in the Elderly"
Joe Verghese, M.D., Albert Einstein College of Medicine: "Latent Mobility Abnormalities and Disability"
2003-2006 Beeson Scholars
Meredith Hawkins, M.D., Albert Einstein College of Medicine: "The Role of Nutrient Excess in Mediating the Insulin Resistance of Aging"
Michael Irizarry, M.D., Harvard Medical School/Massachusetts General Hospital: "Beta-secretase and Alzheimer's Risk with Aging"
Kenneth Langa, M.D., Ph.D., University of Michigan: "Long-term outcomes of Caring for a Disabled Spouse"
Sarah Lisanby, M.D., Columbia University College of Physicians and Surgeons: "Brain Stimulation and Pharmacological Strategies to Reduce the Cognitive Side Effects of ECT in Geriatric Depression"
Jack Parent, M.D., University of Michigan: "Stimulation of Endogenous Neural Stem Cells to Promote Recovery after Stroke"
Henry Paulson, M.D., Ph.D., University of Iowa: "RNA interference (RNAi) as a Novel Therapy for Age-Related Disease"
Elizabeth Phelan, M.D., University of Washington: "Improving Primary Care of Older Adults"
Wendy Post, M.D., Johns Hopkins University School of Medicine: "Vascular Properties and Genetics Associated with Longevity in the Amish"
Norman Sharpless, M.D., University of North Carolina at Chapel Hill: "The Role of the Tumor Suppressor P16 ink4a in Mammalian Aging"
Michael Shlipak, M.D., M.P.H., University of California, San Francisco: "Preventing Heart Failure in Elderly Persons with Chronic Renal Insufficiency"
Reisa Sperling, M.D., Harvard Medical School/Brigham & Women's Hospital: "Investigating the Neural Underpinnings of Memory Impairment in Aging and Early Alzheimer's Disease"
2002-2005 Beeson Scholars
David Casarett, M.D., University of Pennsylvania: "Improving Decision-Making About End-of-Life Care and Promoting Earlier Referral to Hospice"
James Galvin, M.D., Washington University School of Medicine: "In Vitro and In Vivo Models of Synucleinopathies"
Brad Johnson, M.D., Ph.D., University of Pennsylvania School of Medicine: "Functions of the Werner Syndrome Family of Proteins in Telomerase-Deficient Mice and Yeast"
Lorraine Kyne, M.D., M.P.H., Harvard Medical School/Beth Israel Deaconess Medical Center: "Effect of Probiotic Therapy on Clinical Outcome and Immune Response to C. Difficile Infection in Elderly Patients"
Albert La Spada, M.D., Ph.D., University of Washington: "Development of Therapies for Polyglutamine Neurodegeneration and Related Disorders"
Michael Lin, M.D., Weill Medical College of Cornell University: "Mitochondrial DNA Mutations in Aging and AlzheimerÕs Disease"
Robert Marciniak, M.D., Ph.D., UTHSCSA: "Oxidative Stress and Telomere Maintenance: In vitro and In vivo Studies"
Laura Niklason, M.D., Ph.D., Duke University: "Lifespan Extension of Vascular Cells for Tissue Engineering"
Michael Schwarzschild, M.D., Ph.D., Massachusetts General Hospital: "Sorting Out Clues to ParkinsonÕs Disease: Caffeine, Postmenopausal Estrogen and Addiction"
Jurgen Unutzer, M.D., M.P.H., UCLA Neuropsychiatric Institute: "Improving Care for Chronic Pain and Late Life Depression"
2001-2004 Beeson Scholars
Asa Abeliovich, M.D, Ph.D., Columbia University College of Physicians and Surgeons, Molecular Analysis of the Familial Parkinson Disease Genes Parkin and Alpha-Synuclein
Katrin Andreasson, M.D., Johns Hopkins University School of Medicine, Mechanisms of Cyclooxygenase-2 Dependent Neuronal Injury in Aging and Neurodegenerative Disease
Eric Coleman, M.D., M.P.H., University of Colorado Health Science Center, Reducing Care Fragmentation Across Sites of Geriatric Care
Jay Edelberg, M.D., Ph.D., Weill Medical College of Cornell University, Restoration of Senescent Cardiac Angiogenic Activity by Bone Marrow Transplantation
Wesley Ely, M.D., M.P.H., F.C.C.P., Vanderbilt University School of Medicine, The Role of Delirium and Psychoactive Drug Use on Outcomes Following Mechanical Ventilation in Older Persons
Roger Hajjar, M.D., Harvard Medical School, Targeting Signaling Pathways in Aging Hearts by Gene Transfer
James Mastrianni, M.D., Ph.D., University of Chicago School of Medicine, Aging and the Misfolded Protein: Prion Disease as a Model for Disaggregating the Aggregate
Michael Naski, M.D., Ph.D., University of Texas Health Science Center at San Antonio, Matrix Homeostasis and Gene Expression in Aging Cartilage
Cary Reid, M.D., Ph.D., Yale University School of Medicine, Determining the Impact of Back Pain on Physical and Social Disability Among Older Adults
Mary Whooley, M.D., University of California, San Francisco, School of Medicine, Mechanisms of Association Between Depression and Poor Health Outcomes in Older Patients
Kristine Yaffe, M.D., University of California, San Francisco, School of Medicine, Determinants of Cognitive Change and its Outcomes in African-American and White Elders
2000-2003 Beeson Scholars
Brock Beamer, M.D., Johns Hopkins University School of Medicine: "Genetic variations in PPAR- and RxR : Effects on Body Composition and Metabolism in Older Adults"
Gunnar Gouras, M.D., Weill College of Medicine of Cornell University: "Neuronal A-beta Accumulation: Aging and Oxidative Stress"
Mary Beth Hamel, M.D., M.P.H., Harvard Medical School: "Decision Making and Outcomes for Elderly Patients with Surgical Problems"
Joshua Hare, M.D., Johns Hopkins University School of Medicine: "The Role of Nitric Oxide in Aging-Related Cardiovascular Adaptions"
Fuki Hisama, M.D., Yale University School of Medicine: "The Molecular Basis of Aging in Werner Syndrome"
Jason Karlawish, M.D., University of Pennsylvania School of Medicine: "Caregiver and Patient Preferences for the Treatment of Alzheimer's Disease"
Jean Kutner, M.D., M.S.P.H., University of Colorado Health Science Center: "Symptom Management at the End of Life: Decreasing Distress and Improving Quality of Life"
Brett Lauring, M.D., Ph.D., Columbia University College of Physician and Surgeons: "An In- Vitro Assay for Gamma Secretase Processing of the Amyloid Precursor Protein"
Frank Lee, M.D., Ph.D., University of Pennsylvania School of Medicine: "Protein Kinases and Alzheimer's Disease"
R. Sean Morrison, M.D., Mount Sinai School of Medicine: "Interventions to Improve Pain Outcomes"
Scott Small, M.D., Columbia University College of Physician & Surgeons: "Functional Analysis of the Hippocampal Formation in Age-Related Memory Decline"
1999-2002 Beeson Scholars
Jeanne Anderson, M.D., University of Texas Health Science Center at San Antonio: "Clinical Trials in Age-Associated Leukemia and Leukemia-Related Diseases with Correlative Studies of Clonality and Functional Status"
Kenneth Covinsky, M.D., M.P.H., University of California, San Francisco: "Outcomes of Frail Nursing Home-Eligible Elders Living in the Community"
Matthew Frosch, M.D., Ph.D., Harvard Medical School: " Estrogen, Aging and Alzheimer's Disease Mechanisms and Model Systems"
Daniel Laskowitz, M.D., Duke University Medical Center: "Apolipoprotein E, Microglial Activation, and Neurodegenerative Disease"
Dale Leitman, M.D., Ph.D., University of California, San Francisco: " Role of Coactivators in Estrogen Repression of Gene Transcription"
Richard Lin, M.D., University of Texas Health Science Center at San Antonio: "The Role of Oxidative Stress in Aging Effects on Vascular Smooth Muscle Cell Growth and Signal Transduction"
David Lynch, M.D., Ph.D., University of Pennsylvania: "Excitotoxicity in Neurodegenerative Disorders: New Understanding from NMDA Receptor Subtypes"
Edward Marcantonio, M.D., Harvard Medical School: "Reducing Delirium in Post-Acute Care: An Interventional Trial"
Mitchell Nobler, M.D., Columbia University College of Physicians and Surgeons: "Serotonin and PET Neuroimaging in Normal Aging and Geriatric Depression"
Anne Louise Oaklander, M.D., Ph.D., Harvard Medical School: "Cellular Mechanisms of Chronic Neuropathic Pain"
Thomas Rando, M.D., Ph.D., Stanford University School of Medicine: "Mechanisms of Age-Related Muscle Atrophy: The Role of Cellular Antioxidant Defenses"
1998-2001 Beeson Scholars
Helene Benveniste, M.D., Ph.D., Duke University Medical Center: "In Vivo Magnetic Resonance Microscopy and Alzheimer's Disease: Defining and Staging the Progression of Alzheimer's Pathology in Transgenic Mice Overexpressing Beta Amyloid Protein"
Laura Dugan, M.D., Washington University School of Medicine: "Mechanisms of Neuroprotection by C60 Derivatives: Relevance to Oxidative Stress during Aging"
Terri Fried, M.D., Yale University School of Medicine: "A Longitudinal Study of Terminally Ill Patient's Preference for Care"
Anne Kenny, M.D., University of Connecticut Health Center: "Mechanisms of Bone Loss in Older Men with Low Testosterone Levels"
Alison Moore, M.D., M.P.H., UCLA School of Medicine: "Screening for Harmful and Hazardous Drinking in Older Persons"
Thomas Perls, M.D., Harvard Medical School: Familiality of Extreme Longevity and Mitochondrial Longevity-Assurance Genes in Centenarian Subjects"
Eric Peterson, M.D., Duke University Medical Center: "Toward a Rational Use of Revascularization in the Aged"
R. Scott Turner, M.D., Ph.D., University of Michigan Medical School: "The Role of X11a in Amyloid Precursor Protein"
Jeremy Walston, M.D., Johns Hopkins University School of Medicine: "Molecular Etiologies of Age-Related Changes in Body Composition"
Raymond Yung, M.D., University of Michigan Medical School: "Lymphocyte Homing in Aging"
1997-2000 Beeson Scholars
Nir Y. Barzilai, M.D., Albert Einstein College of Medicine: "The Effect of Age-Dependent Increase in Visceral Fat on Insulin Action and Secretion"
Michele F. Bellantoni, M.D., Johns Hopkins University School of Medicine: "Growth Hormone and Sex Steroid Effects on Bone in Older Women"
James R. Burke, M.D., Ph.D., Duke University Medical Center: "Polyglutamine Proteins as a Model System for Studying Protein Aggregation and Cell Death in Aging and Neurodegenerative Disease"
Mark T. D'Esposito, M.D., University of Pennsylvania School of Medicine: "Functional Neuroimaging Studies of Working Memory in Normal Human Aging"
Thomas M. Gill, M.D., Yale University School of Medicine: "Identifying the Events That Precipitate Functional Dependence Among Community-living Elderly Persons"
Bernard F. Godley, M.D., Ph.D., University of Texas Medical Branch: " Role of Oxidative DNA Damage and Repair in Age-Related Macular Degeneration"
Todd E. Golde, M.D., Ph.D., Mayo Clinic Jacksonville, Mayo Medical School: "Proteolytic Generation of the Amyloid b Peptide in Alzheimer's Disease"
Helen Hoenig, M.D., M.P.H., Duke University Medical Center: "An Investigation of the Physical Costs and the Quality of Life Benefits of Wheelchairs for Older Persons"
Elan D. Louis, M.D., College of Physicians & Surgeons of Columbia University: "Functional Correlates of Essential Tremor"
Charles A. Thornton, M.D., University of Rochester School of Medicine: "Pathophysiology of Myotonic Dystrophy, a Progeroid Syndrome"
1996-1999 Beeson Scholars
Christopher M. Callahan, M.D., Indiana University School of Medicine: The Use of Percutaneous Endoscopic Gastrostomy among Older Adults in a Community Setting.
Robert W. Doms, M.D., Ph.D., University of Pennsylvania: STM2, APP, and Alzheimer's disease.
P. Murali Doraiswamy, M.D., Duke University Medical Center: Apolipoprotein E type 4 Allele and Cerebral Metabolism in Relatives at Risk for Familial Alzheimer's Disease.
Harlan M. Krumholz, M.D., Yale University School of Medicine: Clinical Spectrum, Treatment and Outcome of Elderly Congestive Heart Failure Patients.
Makau Lee, M.D., Ph.D., University of Mississippi Medical Center: Studies on Aging, Dietary Restriction and Gastric Mucosal Defense.
Richard F. Loeser, Jr., M.D., Rush Medical College: Growth Factors and Aging in Cartilage.
Karen M. Prestwood, M.D., University of Connecticut Health Center: Bone Turnover and the Response to Estrogen in Older Caucasian, Hispanic and African-American Postmenopausal Women.
May J. Reed, M.D., University of Washington School of Medicine: Angiogenesis, the Extracellular Matrix, and Wound Repair in Aging.
Robert G. Smith, M.D., Ph.D., Baylor College of Medicine: Role of Voltage-Gated Calcium Channel Autoantibodies in Motoneuron Injury in ALS.
1995-1998 Beeson Scholars
Ashley Bush, M.B., B.S., D.P.M, Ph.D., Harvard Medical School: Zinc Exposure as a Risk Factor for Alzheimer's Disease.
Ted M. Dawson, M.D., Ph.D., Johns Hopkins University School of Medicine: Gene Therapy for Neurologic Disorders.
David M. Holtzman, M.D., Washington University School of Medicine: Use of Animal Models and Neuronal Cell Lines to Study Alzheimer's-like Neurodegeneration.
Edward H. Koo, M.D., University of California, San Diego School of Medicine: Focus: The mechanism of amyloid beta-protein (AB) production from the amyloid precursor protein (APP) in neurons.
Mark S. Lachs, M.D., M.P.H., Cornell University Medical College: The Morbidity and Mortality of Elder Abuse.
Frank M. Longo, M.D., Ph.D., University of California, San Francisco School of Medicine: New Strategies for Treating Neurodegenerative Disease.
Richard A. Marottoli, M.D., M.P.H., Yale University School of Medicine: Older Driver Assessment: A Multilevel Approach
Lina M. Obeid, M.D., Medical University of South Carolina: Lipid Signal Transduction in Cellular Senescence.
Peter Reaven, M.D., University of California, San Diego School of Medicine: The Relationship of Aging and Antioxidant Defense Systems to Artherosclerosis.
Alan R. Shuldiner, M.D., University of Maryland School of Medicine: Genetics of Diabetes and Obesity in the Elderly.