News

< Back

Grantee in the News: Inna Slutsky’s Team discovers new Alzheimer’s connections

On July 1, 2014 The Times of Israel reported on 2008 New Investigator Award in Alzheimer’s Disease recipient Inna Slutsky, PhD’s, new research uncovering one of the main reasons for the seizures, memory loss and cognitive impairment suffered by Alzheimer’s patients.

Dr. Slutsky’s team uncovered a molecular mechanism behind hyperactivity in the brains of Alzheimer’s patients.

Accelerated binding of amyloid precursor protein (APP) and amyloid-beta triggers a “signaling cascade” in which messages shared by brain cells are amplified, elevating neuronal activity and essentially “short-circuiting” the brain’s communication network.

The researchers believe that further study, on how to change the structure of APP and engineer molecules that interfere with the binding of amyloid-beta to APP, may lead to a cure for Alzheimer’s disease.

Inna Slutsky, PhD, is a Professor of Cellular/Molecular Neurophysiology and Brain Disorders at the Sagol School of Neuroscience at Tel Aviv University in Tel Aviv, Israel.

By directly effecting more than 5.4 million Americans, Alzheimer’s disease is one of the top public health concerns we face as a nation. To learn more about the biological mechanisms behind Alzheimer’s, visit our InfoAging guide.

More Recent News

View All News >
In Memoriam: Norman Volk, Former AFAR Board Member
In Memoriam: Norman Volk, Former AFAR Board Member
AFAR Grantee in the News: New Research by AFAR Grantee Aditi Gurkar on the molecular index of biological aging published in Aging Cell.
AFAR Grantee in the News: New Research by AFAR Grantee Aditi Gurkar on the molecular index of biological aging published in Aging Cell.
AFAR Grantee in the News: New Research by Dibyadeep Datta on a biomarker that could indicate ensuing Alzheimer's disease published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association
AFAR Grantee in the News: New Research by Dibyadeep Datta on a biomarker that could indicate ensuing Alzheimer's disease published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association
AFAR Grantee in the News: New Research by Mark E. Kleinman on histone dynamics, cellular senescence, and aging in Aging Cell.
AFAR Grantee in the News: New Research by Mark E. Kleinman on histone dynamics, cellular senescence, and aging in Aging Cell.
AFAR News: Gareth W. Shepherd, PhD, and Robert W. Stearns elected to Board of Directors
AFAR News: Gareth W. Shepherd, PhD, and Robert W. Stearns elected to Board of Directors
AFAR leadership on impact of four AFAR-led NIA programs in special issue of JAGS
AFAR leadership on impact of four AFAR-led NIA programs in special issue of JAGS
AFAR experts in the News: Scientific Director Nir Barzilai and several grantees co-author "Validation of Biomarkers of Aging" in Nature Medicine
AFAR experts in the News: Scientific Director Nir Barzilai and several grantees co-author "Validation of Biomarkers of Aging" in Nature Medicine
AFAR Media Briefing: Aging and Presidential Election, Transcript Now Available
AFAR Media Briefing: Aging and Presidential Election, Transcript Now Available
Leadership in the News: Scientific Director Nir Barzilai, MD, discusses longevity, therapeutics, and more on The Doctor’s Farmacy podcast
Leadership in the News: Scientific Director Nir Barzilai, MD, discusses longevity, therapeutics, and more on The Doctor’s Farmacy podcast