Yongjie Zhang, PhD

Senior Research Fellow, Mayo Clinic College of Medicine

Generation and Characterization of M337V TDP-43 Transgenic Mice: A Possible Model For TDP-43 Proteinopathy Dr. Zhang will develop a novel transgenic mouse model of Amyotrophic lateral sclerosis (ALS). The model will express a nuclear protein called TDP-43 which is known to clump abnormally in a number of degenerative diseases. A mutation of the TDP-43...

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Shuanhu (Joe) Zhou, PhD

Instructor, Brigham and Women's Hospital

The Effects of Niche on Mesenchymal Stem Cells During Human Skeletal Aging Bone fractures are a major source of disability among the elderly. Bone is a living tissue which deteriorates with aging due to an imbalance between the activity of cells that continuously produce new bone and cells which reabsorb old bone. Cells which produce...

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David W. Walker, PhD

Assistant Professor, University of California, Los Angeles

Investigating the Life-extending Mechanisms of Apolipoprotein D: An Evolutionary Conserved Modulator of Oxidative Stress and Aging In fruitflies, mice and plants, Apolipoprotein D (ApoD) -- a gene that has been linked to a number of age-related diseases in humans, including Alzheimer's disease -- may play a role in protecting cells against free radicals and...

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Nicolas Rohleder, PhD

Assistant Professor, Brandeis University

Determinants and Consequences of the Acute Stress-induced Inflammatory Response in Human Aging Rates of aging may be affected by how people handle stress. Dr. Rohleder's research will test the healthy and unhealthy response patterns of older adults to stress to determine if specific patterns affect biological, emotional and cognitive aging. One focus of the...

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Raul Mostoslavsky, MD, PhD

Assistant Professor, Massachusetts General Hospital Cancer Center, Harvard Medical School

SIRT6, a Chromatin Regulator of Glucose Homeostasis and Genomic Stability Dr. Mostoslavsky will investigate whether SIRT6 modulates glucose metabolism and DNA repair and whether this function is important in modulating aging and age-related diseases. Cells require glucose to provide energy for metabolic activity and are able to trigger an adaptive response to ensure their survival...

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