James R. Mitchell, PhD

Assistant Professor of Genetics and Complex Diseases, Harvard School of Public Health

Testing Small Molecule Inhibitors of GH/IGF-1 Receptor Signaling as Dietary Restriction Mimetics Against Acute Stress in vivo Dr. Mitchell's research seeks to understand the role that growth factor signaling plays in the regulation of lifespan and stress resistance. Decreased growth factor signaling through genetic and dietary means (caloric restriction) may play a part...

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Goldis Malek, PhD

Assistant Professor, Albert Eye Research Institute

Osteopontin Regulation of Choroidal Neovascular Fibrosis through Macrophages Age-related macular degeneration (AMD) is a leading cause of vision loss in Americans 60 years of age and older. It occurs in two forms: wet and dry. Wet AMD occurs when abnormal blood vessels behind the retina start to grow under the macula - the part of the...

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Jonathan H. Lin, MD

Assistant Professor, University of California San Diego

Cellular Responses to Chronic Protein Misfolding Protein misfolding underlies many age-related diseases including Alzheimer's disease, Parkinson's disease and macular degeneration. Dr. Lin will research the mechanisms by which human cells cope and adapt to protein misfolding or die. This may shed light into the pathogenesis of age-related diseases which could lead to new...

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Susan A. Krum, PhD

Assistant Professor, University of California, Los Angeles

Gene Regulation by Estrogen in Adipose of Aging Bone Dr. Krum is studying the role estrogen plays in regulating bone and fat cells. More than 10 million Americans - most commonly post-menopausal women -- have osteoporosis. While estrogen provides protection against bone fractures by increasing bone mass and lowering fat accumulation, the mechanism by which it...

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Martin L. Duennwald, PhD

Scientist, Boston Biomedical Research Institute

The Systems Biology of Age-Dependent Protein Misfolding A number of age-related neurological diseases such as Alzheimer's disease and Parkinson's Disease seem to be caused by misfolding of otherwise normal proteins inside brain cells. Proteins to perform their normal function have complex folding patterns like origami, and if normal folding is disrupted not only...

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