Lucia Pastorino, PhD

Instructor in Medicine, Beth Israel Deaconess Medical Center

Role of the Prolyl Isomerase Pin1 in the Modulation of PS1 Activity Proteins regulate the activity, the physiology, and the life of the cell. They exist as three dimensional structures that can undergo changes in their spatial conformation. One could imagine proteins as balls of wool (as it exists in its normal folded state), together...

View More

Esther Oh, MD

Assistant Professor, Johns Hopkins University

Oral Glucose Tolerance Test For Alzheimer's Disease Biomarker Development Measuring amyloid levels in the cerebrospinal fluid (CSF) may be a useful way to identify people who have Alzheimer's disease but is difficult to obtain because the procedure is invasive. A much less invasive method - a simple blood test - has not been shown...

View More

Gad A. Marshall, MD

Instructor in Neurology, Associate Neurologist, Brigham and Women's Hospital

Amyloid Deposition and Frontally Mediated Symptoms in MCI Patients with mild cognitive impairment (MCI), often a precursor to Alzheimer's disease (AD), may present with apathy (loss of interest, lack of motivation and social withdrawal) and executive dysfunction (impairment in complex attention, working memory, organization, and reasoning) that leads to impairment in instrumental activities of...

View More

Raquel L. Liberman, PhD

Assistant Professor, Georgia Tech

Crystal Structure of an Intramembrane Asparyl Protease Presenilin is a critical component of a large enzyme complex that plays a key role in producing, from a precursor protein, the range of peptides (strings of amino acids) that form the amyloid substances found in plaques, blood vessels and neurons of the brains of patients with Alzheimer'...

View More

Ehud Cohen, PhD

Lecturer, The Hebrew University of Jerusalem

Roles of Peptidylprolyl Cis/Trans Isomerases in the Regulation of Aging and Countering Alzheimer's Disease Most neurodegeneration that has a familial mutation-link occurs in a person in their 40s, while most nonhereditary cases occur in people beginning in their 60s or later. Why neurodegenerative disorders emerge late in life and why distinct disorders share common...

View More