2014

Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty


Jason Karpac, PhD

Assistant Professor, Texas A&M University Health Science Center (College of Medicine)

Inter-organ communication in the systemic control of aging

Over the past decade, studies in both insects and mammals have shown that blood-borne factors can dramatically affect the rate of tissue aging. It is thus possible that aging in one tissue can promote aging in other tissues through the production of specific factors. Dr. Karpac has developed a fruit fly model which allows him to describe the age-related hormonal interactions between muscle tissue and the intestine, which are tissues that play an important role in controlling lifespan of the fly.

Dr. Karpac will explore ways by which these signals and interactions may coordinate the aging process across tissues and may affect longevity.

More 2014 Recipients of this Grant

Alexander Soukas, MD, PhD

Dietary modulation of lifespan by target of rapamycin complex 2

Christin Burd, PhD

Beyond cellular senescence: defining the meaning of p16INK4a expression in vivo

Fabio Demontis, PhD

Translational Regulation of Selective Autophagy by 4E-BP during Muscle Aging in Drosophila

Jason Butler, PhD

Rejuvenation of aged vascular niches to enhance hematopoietic function

Jason MacGurn, PhD

Molecular Mechanisms of Ubiquitin Homeostasis During Cellular Stress

Subhash Katewa, PhD

Role of circadian clocks in mediating effects of Dietary Restriction on lifespan extension

Ilya Finkelstein, PhD

High-Throughput Studies of Protein Homeostasis in Aging Cells

Jason Held, PhD

Investigating the redox biology of aging in C. elegans