Advancing Research
by funding Grant Programs and Fellowships
Driving Innovation
by guiding studies such as the FAST Initiative, the SuperAgers Initiative, and the TAME Trial
Furthering the Field
by supporting the infrastructure of three NIA Initiatives and leading the Amplifying Geroscience Initiative.
Top Breakthroughs driven by AFAR Experts
Delaying Disease by Targeting Aging
Saving Costs by Extending Healthspan
What are the Hallmarks of Aging?
How and Why Do We Age?
What is Geroscience?
What is the Longevity Dividend?
What's Next in aging research?
Many age-related diseases, including Alzheimer’s disease, Parkinson’s disease and Amyotrophic Lateral Sclerosis, are associated with the misfolding and aggregation of proteins. Dr. Zid is looking at a specific class of proteins that have a high tendency to accumulate and he will investigate how they affect the cell during aging in the model organism yeast.
Dr. Zid aims to characterize the aggregation of these RNA-binding proteins and identify the regulatory mechanisms by which mRNAs (messenger RNA molecules) are differentially localized in the cytoplasm— the parts of a cell excluding the nucleus—during aging.
Since many of these aggregation-prone RNA-binding proteins have strong links to neurodegenerative diseases in humans, his research could provide novel insights into aging and the causes of neurodegenerative disorders.
